Miss Vavoom is one of the main female characters of the show. Due to her seductive nature, she is always conquered by Droopy, and mainly the target of McWolf or some other villain. Sometimes she is in a few of the Tom and Jerry sketches. Her character was based on Red Hot Riding Hood and Jessica Rabbit from Who Framed Roger Rabbit. She was voiced by Teresa Ganzel (The Johnny Carson Show, New Hollywood Squares).

In the Polish dub, she was voiced by Barbara Bursztynowicz (also Jerry's VA).